![]() We have demonstrated the applicability of our time-varying cell stimulations approach to discriminate competing signaling models and signaling mechanisms ( Jashnsaz et al., 2020). By implementing an integrated experimental and computational modeling framework, we have found that diverse time-varying cell stimulations result in distinct signaling response dynamics, which better constrain signaling model parameters, and improve predictions of WT and mutant pathway responses as compared to models identified using standard step-like stimulation responses ( Jashnsaz et al., 2020). ![]() We have demonstrated that the rates by which these changes occur are critical for cellular responses and fate decisions ( Johnson et al., 2021 Thiemicke et al., 2019 Thiemicke and Neuert, 2021). Cells in their natural environment experience stimuli that change gradually over time.
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